Effexor XR (Venlafaxine)

Use Effexor XR as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Effexor XR comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Effexor XR refilled.
Take Effexor XR by mouth with food.
Effexor XR works best if it is taken at the same time each day. Continue to take Effexor XR even if you feel well. Do not miss any doses.
Do not suddenly stop taking Effexor XR without checking with your doctor. Side effects may occur. They may include mental or mood changes, numbness or tingling of the skin, dizziness, drowsiness, confusion, headache, increased sweating, loss of coordination or balance, nausea, ringing in the ears, seizures, tremor, trouble sleeping, or unusual tiredness. You will be closely monitored when you start Effexor XR and whenever a change in dose is made.

Drug Class and Mechanism

Effexor XR is a serotonin and norepinephrine reuptake inhibitor (SNRI). It works by restoring the balance of certain natural substances in the brain (serotonin and norepinephrine), which helps to improve certain mood problems.

Missed Dose

If you miss a dose of Effexor XR, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Storage

Store Effexor XR at room temperature (68F to 77F or 20C to 25C). Keep Effexor XR away from children.

Do NOT use Effexor XR if:

• you are allergic to any ingredient in Effexor XR
• you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), selegiline, or St. Johns wort within the last 14 days
• you are taking a fenfluramine derivative (eg, dexfenfluramine), methylene blue, sibutramine, nefazodone, or tryptophan

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Effexor XR. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you or a family member has a history of bipolar disorder (manic-depression), other mental or mood problems, suicidal thoughts or attempts, or alcohol or substance abuse
• if you have a history of seizures, heart problems (eg, heart failure, irregular heartbeat), abnormal electrocardiogram (ECG), recent heart attack, high blood pressure, overactive thyroid, liver problems, lung problems, kidney problems, stomach or bowel bleeding, blood or bleeding problems, increased eye pressure (eg, glaucoma), nervous system problems, or metabolism problems
• if you are dehydrated, have low blood sodium levels, or drink alcohol
• if you will be having electroconvulsive therapy (ECT)

Some MEDICINES MAY INTERACT with Effexor XR. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Certain diet medicines (eg, phentermine, fenfluramine), linezolid, lithium, MAOIs (eg, phenelzine), methylene blue, metoclopramine, nefazodone, rasagiline, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), serotonin and norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine), serotonin 5-HT1 receptor agonists (eg, sumatriptan), sibutramine,St. Johns wort, tramadol, trazodone, tricyclic antidepressants (eg, amitriptyline), or tryptophan because severe side effects, such as a reaction that may include fever, rigid muscles, blood pressure changes, mental changes, confusion, irritability, agitation, delirium, and coma, may occur
• Anticoagulants (eg, warfarin), aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of bleeding, including stomach bleeding, may be increased
• Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood sodium levels may be increased
• Azole antifungals (eg, ketoconazole) or cimetidine because they may increase the risk of Effexor XRs side effects
• Cyproheptadine because it may decrease Effexor XRs effectiveness
• Aripiprazole, haloperidol, phenothiazines (eg, chlorpromazine, thioridazine), or risperidone because the risk of their side effects may be increased by Effexor XR