Sinequan (Doxepin)

Use Sinequan as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Sinequan comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Sinequan refilled.
Take Sinequan by mouth with or without food.
Taking Sinequan at bedtime may help reduce side effects (eg, daytime drowsiness). Discuss this possibility with your doctor.

Drug Class and Mechanism

Sinequan is a tricyclic antidepressant. It is not known exactly how it works. It may increase the activity of certain chemicals in the brain, which help elevate mood.

Missed Dose

If you miss a dose of Zyvox, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Storage

Sinequan should be stored below 86 degrees F (30 degrees C) in a tight, light resistant container.

Do NOT use Sinequan if:

• you are allergic to any ingredient in Sinequan or to other tricyclic antidepressants
• you have certain prostate problems (eg, asymptomatic prostatic hypertrophy), glaucoma, or trouble urinating
• you are taking clonidine, an H1 antagonist (eg, astemizole, terfenadine), or ibutilide, or you have taken a monoamine oxidase inhibitor (MAOI) (eg, furazolidone, phenelzine, isocarboxazid) within the past 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Sinequan . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of heart problems, seizures (eg, epilepsy), overactive thyroid, prostate problems (eg, benign prostatic hypertrophy [BPH]), blood problems (eg, porphyria), other mental or mood problems, suicidal thoughts or attempts, or alcohol abuse

Some MEDICINES MAY INTERACT with Sinequan . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Antiarrhythmics (eg, quinidine, propafenone, flecainide), antifungal medicines (eg, fluconazole, terbinafine), carbamazepine, cimetidine, mibefradil, phenothiazines (eg, chlorpromazine, thioridazine), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine, sertraline) because they may increase the risk of Sinequan 's side effects
• Anticoagulants (eg, warfarin), H1 antagonists (eg, astemizole, terfenadine), ibutilide, sulfonylureas (eg, tolazamide, glipizide), sympathomimetics (eg, phenylephrine, pseudoephedrine), or tramadol because the risk of their side effects may be increased by Sinequan
• Clonidine, guanadrel, guanethidine, or guanfacine because their effectiveness may be decreased by Sinequan
• MAOIs (eg, furazolidone, phenelzine, isocarboxazid) because severe toxic effects may occur